A Fatal case of Epstein-Barr Virus-Induced Haemophagocytic Lymphohistiocytosis in a young male
نویسندگان
چکیده
Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially lethal condition due to dysfunctional immune response causing severe inflammatory syndrome. Epstein-Barr virus (EBV) – induced HLH form of secondary HLH, very serious presentation an otherwise benign viral infection. Here we present case 31 year old previously healthy male with prolonged fever and constitutional symptoms, eventually diagnosed have EBV He had refractory treatment regimen etoposide dexamethasone followed by Rituximab therapy succumbed septic shock.
منابع مشابه
epstein-barr virus-induced hemophagocytic lymphohistiocytosis.
hemophagocytic lymphohistiocytosis (hlh) is one of the complications of epstein-barr virus (ebv) infection. although the patients who have developed hlh following ebv have normal immune system, there are a few patients with ebv-induced immune deficiency who develop hlh as well. here, we describe the case of a 10-year-old girl with neurological complications caused by ebv-induced hlh. the patien...
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Haemophagocytic lymphohistiocytosis (HLH) is a life threatening complication of Epstein-Barr virus (EBV) infection. The anti-CD20 antibody rituximab depletes B cells, leading to improved outcomes for patients with EBV-associated B-lymphoproliferative disorders. To gather data on the use of rituximab in EBV-HLH, we performed a retrospective investigation involving 42 EBV-HLH patients who had rec...
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Familial hemophagocytic lymphohistiocytosis (FHL) is a fatal disease of early infancy caused by defective natural killer cell activity and is characterized by fever, organomegaly, pancytopenia, and coagulopathy. Disease-causing mutations have been found in perforin, Munc 13-4 and syntaxin-11 genes. We herein describe a case of late-onset FHL with syntaxin-11 mutation in a six-year-old boy in wh...
متن کاملEpstein-Barr Virus-Induced Hemophagocytic Lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is one of the complications of Epstein-Barr virus (EBV) infection. Although the patients who have developed HLH following EBV have normal immune system, there are a few patients with EBV-induced immune deficiency who develop HLH as well. Here, we describe the case of a 10-year-old girl with neurological complications caused by EBV-induced HLH. The patien...
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Background: Epstein-Bar virus (EBV) causes infectious mononucleosis in more than 90% of children. Rarely, mononucleosis may lead to malignancy. The aim the current study was to introduce a child with mononucleosis and persistent adenopathy. Case report: A 4-year-old male patient presented with complaints of fever, shortness of breath and sore throat. He was treated with antibiotics and prednis...
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ژورنال
عنوان ژورنال: Jaffna medical journal
سال: 2021
ISSN: ['0379-3877', '2651-0200']
DOI: https://doi.org/10.4038/jmj.v33i2.138